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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1995 1
1996 1
1998 2
1999 2
2000 1
2001 1
2002 3
2003 1
2004 5
2005 3
2006 3
2007 4
2008 3
2009 10
2010 16
2011 14
2012 13
2013 11
2014 18
2015 13
2016 18
2017 14
2018 16
2019 14
2020 9
2021 12
2022 10
2023 7
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200 results

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Page 1
Nidogen-2 Maintains the Contractile Phenotype of Vascular Smooth Muscle Cells and Prevents Neointima Formation via Bridging Jagged1-Notch3 Signaling.
Mao C, Ma Z, Jia Y, Li W, Xie N, Zhao G, Ma B, Yu F, Sun J, Zhou Y, Cui Q, Fu Y, Kong W. Mao C, et al. Circulation. 2021 Oct 12;144(15):1244-1261. doi: 10.1161/CIRCULATIONAHA.120.053361. Epub 2021 Jul 28. Circulation. 2021. PMID: 34315224
Nidogen-2 maintained the VSMC contractile phenotype via Jagged1-Notch3 signaling but not Notch1 or Notch2 signaling. Nidogen-2 enhanced Jagged1 and Notch3 interaction and subsequent Notch3 activation. ...CONCLUSIONS: Nidogen-2 maintains the contractile phenot …
Nidogen-2 maintained the VSMC contractile phenotype via Jagged1-Notch3 signaling but not Notch1 or Notch2 signaling. Nidogen-2 enhanc …
Precision medicine for human cancers with Notch signaling dysregulation (Review).
Katoh M, Katoh M. Katoh M, et al. Int J Mol Med. 2020 Feb;45(2):279-297. doi: 10.3892/ijmm.2019.4418. Epub 2019 Dec 4. Int J Mol Med. 2020. PMID: 31894255 Free PMC article. Review.
NOTCH1, NOTCH2, NOTCH3 and NOTCH4 are transmembrane receptors that transduce juxtacrine signals of the delta-like canonical Notch ligand (DLL)1, DLL3, DLL4, jagged canonical Notch ligand (JAG)1 and JAG2. Canonical Notch signaling activates the transcription of BMI1 proto-o …
NOTCH1, NOTCH2, NOTCH3 and NOTCH4 are transmembrane receptors that transduce juxtacrine signals of the delta-like canonical Notch lig …
JAGGED1/NOTCH3 activation promotes aortic hypermuscularization and stenosis in elastin deficiency.
Dave JM, Chakraborty R, Ntokou A, Saito J, Saddouk FZ, Feng Z, Misra A, Tellides G, Riemer RK, Urban Z, Kinnear C, Ellis J, Mital S, Mecham R, Martin KA, Greif DM. Dave JM, et al. J Clin Invest. 2022 Mar 1;132(5):e142338. doi: 10.1172/JCI142338. J Clin Invest. 2022. PMID: 34990407 Free PMC article.
Specifically, reduced elastin increased levels of gamma-secretase, activated NOTCH3 intracellular domain, and downstream genes. Notch3 deletion or pharmacological inhibition of gamma-secretase attenuated aortic hypermuscularization and stenosis in Eln-/- mutants. El …
Specifically, reduced elastin increased levels of gamma-secretase, activated NOTCH3 intracellular domain, and downstream genes. No …
Prognostic Subcellular Notch2, Notch3 and Jagged1 Localization Patterns in Early Triple-negative Breast Cancer.
Strati TM, Kotoula V, Kostopoulos I, Manousou K, Papadimitriou C, Lazaridis G, Lakis S, Pentheroudakis G, Pectasides D, Pazarli E, Christodoulou C, Razis E, Pavlakis K, Magkou C, Chrisafi S, Aravantinos G, Bafaloukos D, Papakostas P, Gogas H, Kalogeras KT, Fountzilas G. Strati TM, et al. Anticancer Res. 2017 May;37(5):2323-2334. doi: 10.21873/anticanres.11570. Anticancer Res. 2017. PMID: 28476798
We evaluated cytoplasmic (c), membranous (m) and nuclear (n) protein localization. RESULTS: c-Notch2 (35% positive tumors), c-Notch3 (63%), c-Jag1 (43%), m-Notch3 (23%) and n-Jag1 (17%) were analyzed individually and by using hierarchical clustering fo …
We evaluated cytoplasmic (c), membranous (m) and nuclear (n) protein localization. RESULTS: c-Notch2 (35% positive tumors), c-Notch3 …
JAGGED-NOTCH3 signaling in vascular remodeling in pulmonary arterial hypertension.
Zhang Y, Hernandez M, Gower J, Winicki N, Morataya X, Alvarez S, Yuan JX, Shyy J, Thistlethwaite PA. Zhang Y, et al. Sci Transl Med. 2022 May 4;14(643):eabl5471. doi: 10.1126/scitranslmed.abl5471. Epub 2022 May 4. Sci Transl Med. 2022. PMID: 35507674
Within the pulmonary arterial tree, the NOTCH3 pathway is crucial in controlling vascular smooth muscle cell proliferation and maintaining smooth muscle cells in an undifferentiated state. ...A new monoclonal antibody for the treatment of PAH, which blocks JAG-1 cis- and t …
Within the pulmonary arterial tree, the NOTCH3 pathway is crucial in controlling vascular smooth muscle cell proliferation and mainta …
Insufficient GDF15 expression predisposes women to unexplained recurrent pregnancy loss by impairing extravillous trophoblast invasion.
Lyu C, Ni T, Guo Y, Zhou T, Chen ZJ, Yan J, Li Y. Lyu C, et al. Cell Prolif. 2023 Dec;56(12):e13514. doi: 10.1111/cpr.13514. Epub 2023 Jun 4. Cell Prolif. 2023. PMID: 37272232 Free PMC article.
Moreover, GDF15 knockdown significantly reduced the invasiveness of both HTR-8/SVneo cells and primary human EVT cells and suppressed the Jagged-1 (JAG1)/NOTCH3/HES1 pathway activity, and JAG1 overexpression rescued the invasion phenotype of the GDF15 knockdo …
Moreover, GDF15 knockdown significantly reduced the invasiveness of both HTR-8/SVneo cells and primary human EVT cells and suppressed the Ja …
Jagged-1 and Notch3 juxtacrine loop regulates ovarian tumor growth and adhesion.
Choi JH, Park JT, Davidson B, Morin PJ, Shih IeM, Wang TL. Choi JH, et al. Cancer Res. 2008 Jul 15;68(14):5716-23. doi: 10.1158/0008-5472.CAN-08-0001. Cancer Res. 2008. PMID: 18632624 Free PMC article.
Interaction of Notch3-expressing ovarian cancer cells with Jagged-1-expressing feeder cells activated the promoter activity of candidate Notch3 target genes, and this activity was attenuated by Notch3 siRNA. ...In Notch3-expressing ovarian cancer cells …
Interaction of Notch3-expressing ovarian cancer cells with Jagged-1-expressing feeder cells activated the promoter activity of candid …
Notch3/Jagged1 circuitry reinforces notch signaling and sustains T-ALL.
Pelullo M, Quaranta R, Talora C, Checquolo S, Cialfi S, Felli MP, te Kronnie G, Borga C, Besharat ZM, Palermo R, Di Marcotullio L, Capobianco AJ, Gulino A, Screpanti I, Bellavia D. Pelullo M, et al. Neoplasia. 2014 Dec;16(12):1007-17. doi: 10.1016/j.neo.2014.10.004. Neoplasia. 2014. PMID: 25499214 Free PMC article.
We provide evidence that Notch-specific ligand Jagged1 is a new Notch3 signaling target gene. This essential event justifies an aberrant Notch3/Jagged1 cis-expression inside the same cell. Moreover, we demonstrate in Notch3-IC-overexpressing T lymphoma cells …
We provide evidence that Notch-specific ligand Jagged1 is a new Notch3 signaling target gene. This essential event justifies an aberr …
NOTCH3 is expressed in human apical papilla and in subpopulations of stem cells isolated from the tissue.
Jamal M, Chogle SM, Karam SM, Huang GT. Jamal M, et al. Genes Dis. 2015 Sep;2(3):261-267. doi: 10.1016/j.gendis.2015.05.003. Epub 2015 May 30. Genes Dis. 2015. PMID: 26989760 Free PMC article.
Our in situ immunostaining showed that in the AP NOTCH3 and CD146 were co-expressed and associated with blood vessels having NOTCH3 located more peripherally. In cultured SCAP, NOTCH3 and JAG1 were co-expressed. Flow cytometry analysis showed that 7%, …
Our in situ immunostaining showed that in the AP NOTCH3 and CD146 were co-expressed and associated with blood vessels having NOTCH …
200 results